Project mission
The project’s aim consists in a detailed study of a specific range of cells, the so called Th1/17 cells, whose massive production is related to organism’s response in patients affected by Chron’s disease. In fact, this reaction is part of a wider series of consequences generated by that chronic gastrointestinal disorder which causes an exaggerated adaptive immune answer in the gut microbiota. In genetically predisposed subjects, the cells analysed in this context induces a pro-inflammatory response to specific bacteria, such as Escherichia coli. The main goal od the project is thus to study the activation of Th1/17 cells in relation to the presence of that kind of bacteria in the gut microbiota.
